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KCNK3 recombinant protein :: Potassium channel subfamily K member 3 (KCNK3) Recombinant Protein

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Catalog # MBS7017744
Unit / Price
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  0.01 mg  /  $535 +1 FREE 8GB USB
  0.05 mg  /  $785 +1 FREE 8GB USB
  0.1 mg  /  $1,240 +1 FREE 8GB USB
SDS-Page
Product Name

Potassium channel subfamily K member 3 (KCNK3), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Potassium channel subfamily K member 3 (KCNK3)

Product Synonym Gene Name
TASK; TASK1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7017744 COA
Sequence Positions
1-394.Full length.
Sequence
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA RYNLSQGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTLVRYLL HRAKKGLGMR RADVSMANMV LIGFFSCIST LCIGAAAFSH YEHWTFFQAY YYCFITLTTI GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG GRYSDTPSRR CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV
OMIM
603220
3D Structure
ModBase 3D Structure for O14649
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol.
Tag Information
Tag type will be determined during the manufacturing process.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of KCNK3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for KCNK3 recombinant protein
Application Notes for KCNK3 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.

KCNK3 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for KCNK3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,518 Da
NCBI Official Full Name
potassium channel subfamily K member 3
NCBI Official Synonym Full Names
potassium two pore domain channel subfamily K member 3
NCBI Official Symbol
KCNK3  [Similar Products]
NCBI Official Synonym Symbols
OAT1; PPH4; TASK; TBAK1; K2p3.1; TASK-1
  [Similar Products]
NCBI Protein Information
potassium channel subfamily K member 3
UniProt Protein Name
Potassium channel subfamily K member 3
UniProt Synonym Protein Names
Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1
UniProt Gene Name
KCNK3  [Similar Products]
UniProt Synonym Gene Names
TASK; TASK1; Two pore K(+) channel KT3.1  [Similar Products]
UniProt Entry Name
KCNK3_HUMAN
NCBI Summary for KCNK3
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for KCNK3
KCNK3: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: cytosol; integral to plasma membrane; plasma membrane

Molecular Function: ion channel activity; open rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: brain development; potassium ion transport; reduction of cytosolic calcium ion concentration; response to drug; stabilization of membrane potential; synaptic transmission

Disease: Pulmonary Hypertension, Primary, 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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