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KCNMB1 elisa kit :: Sheep Calcium-activated potassium channel subunit beta-1 (KCNMB1) ELISA Kit

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Catalog # MBS7238751
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KCNMB1 elisa kit
Product Name

Calcium-activated potassium channel subunit beta-1 (KCNMB1), ELISA Kit

Full Product Name

Sheep Calcium-activated potassium channel subunit beta-1 (KCNMB1) ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 608622
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of KCNMB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for KCNMB1purchase
MBS7238751 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcium-activated potassium channel subunit beta-1 (KCNMB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNMB1. The ELISA analytical biochemical technique of the MBS7238751 kit is based on KCNMB1 antibody-KCNMB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNMB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNMB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for KCNMB1 elisa kit
NCBI/Uniprot data below describe general gene information for KCNMB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,858 Da
NCBI Official Full Name
calcium-activated potassium channel subunit beta-1
NCBI Official Synonym Full Names
potassium large conductance calcium-activated channel, subfamily M, beta member 1
NCBI Official Symbol
KCNMB1  [Similar Products]
NCBI Official Synonym Symbols
hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1
  [Similar Products]
NCBI Protein Information
calcium-activated potassium channel subunit beta-1; BK channel subunit beta-1; maxi K channel subunit beta-1; charybdotoxin receptor subunit beta-1; large conductance Ca2+-activated K+ channel beta 1 subunit; calcium-activated potassium channel, subfamily M subunit beta-1
UniProt Protein Name
Calcium-activated potassium channel subunit beta-1
UniProt Synonym Protein Names
BK channel subunit beta-1; BKbeta; BKbeta1; Hbeta1; Calcium-activated potassium channel, subfamily M subunit beta-1; Calcium-activated potassium channel subunit beta; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta
UniProt Gene Name
KCNMB1  [Similar Products]
UniProt Synonym Gene Names
BKbeta; BKbeta1; Hbeta1; Calcium-activated potassium channel subunit beta; Slo-beta  [Similar Products]
UniProt Entry Name
KCMB1_HUMAN
NCBI Summary for KCNMB1
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNMB1
KCNMB1: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: voltage-gated potassium channel complex; plasma membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity

Biological Process: synaptic transmission; detection of calcium ion; blood coagulation; potassium ion transport

Disease: Hypertension, Diastolic, Resistance To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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