• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

KGF recombinant protein

Scan QR to view Datasheet
Catalog # MBS355571
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $660 +1 FREE 8GB USB
  1 mg  /  $3,660 +4 FREE 8GB USB
KGF recombinant protein
Product Name

KGF, Recombinant Protein

Popular Item
Full Product Name

KGF, FGF7 Protein (Active)

Product Synonym Names
Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; KGF; FGF7; Keratinocyte Growth Factor; KGF Protein (Active)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 15; NC_000015.9 (49715375..49779523). Location: 15q21.2
OMIM
148180
3D Structure
ModBase 3D Structure for P21781
Host
E Coli
Form/Format
Lyophilized
Dimers
< 1% by SDS-PAGE
Endotoxin Level
< 0.1 ng/ug (1 EU/ug) by LAL test
Reconstitution
Reconstitute with sterile 18MΩ-cm H2O.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Preparation and Storage
Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term. Avoid repeated freeze and thaw cycles
Other Notes
Small volumes of KGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
KGF recombinant protein
Recombinant human KGF protein with molecular weight 18.9 kDa.
The Keratinocyte Growth Factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. KGF was both acid and heat labile and consisted of a single polypeptide chain of approximately 28 kDa. Lack of mitogenic activity on either fibroblasts or endothelial cells indicated that KGF possessed a target cell specificity distinct from any previously characterized growth factor. Microsequencing revealed an amino-terminal sequence containing no significant homology to any known protein. The release of this growth factor by human embryonic fibroblasts raises the possibility that KGF may play a role in mesenchymal stimulation of normal epithelial cell proliferation. FGF7 and FGF22 promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers. Terauchi et al. (2010) concluded that specific FGFs act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain.
Applications Tested/Suitable for KGF recombinant protein
SDS-PAGE
NCBI/Uniprot data below describe general gene information for KGF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
22,509 Da
NCBI Official Full Name
Keratinocyte growth factor
NCBI Official Synonym Full Names
fibroblast growth factor 7
NCBI Official Symbol
NCBI Official Synonym Symbols
KGF; HBGF-7
  [Similar Products]
NCBI Protein Information
fibroblast growth factor 7; FGF-7; keratinocyte growth factor; heparin-binding growth factor 7
UniProt Protein Name
Fibroblast growth factor 7
UniProt Synonym Protein Names
Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor
UniProt Gene Name
UniProt Synonym Gene Names
KGF; FGF-7; HBGF-7  [Similar Products]
UniProt Entry Name
FGF7_HUMAN
NCBI Summary for KGF
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for KGF
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Ref.4 Ref.6

Subunit structure: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.4 Ref.5 Ref.6

Subcellular location: Secreted.

Tissue specificity: Epithelial cell.

Sequence similarities: Belongs to the heparin-binding growth factors family.
Product References and Citations for KGF recombinant protein
1. Rubin, J. S., Osada, H., Finch, P. W., Taylor, W. G., Rudikoff, S., Aaronson, S. A. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc. Nat. Acad. Sci. 86: 802-806, 1989. 2. Terauchi, A., Johnson-Venkatesh, E. M., Toth, A. B., Javed, D., Sutton, M. A., Umemori, H. Distinct FGFs promote differentiation of excitatory and inhibitory synapses. Nature 465: 783-787, 2010.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000