NP_061159.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
152,998 Da
NCBI Official Full Name
cell migration-inducing and hyaluronan-binding protein
NCBI Official Synonym Full Names
cell migration inducing protein, hyaluronan binding
NCBI Protein Information
cell migration-inducing and hyaluronan-binding protein; colon cancer secreted protein 1
UniProt Protein Name
Cell migration-inducing and hyaluronan-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
CEMIP_HUMAN
UniProt Comments for KIAA1199
Function: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.4 PublicationsManual assertion based on experiment in:Ref.10
Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.2 PublicationsManual assertion based on experiment in:Ref.14
Enzyme regulation: Activity is up-regulated by histamine.1 PublicationManual assertion based on experiment in:Ref.14
Research Articles on KIAA1199
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Diseases associated with KIAA1199 elisa kit
Organs/Tissues associated with KIAA1199 elisa kit
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