NP_032481.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,383 Da
NCBI Official Full Name
plasma kallikrein
NCBI Official Synonym Full Names
kallikrein B, plasma 1
NCBI Protein Information
plasma kallikrein; kininogenin; fletcher factor; kallikrein 3, plasma; plasma prekallikrein; antigen, prostate specific
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikreinCleaved into the following 2 chains:Plasma kallikrein heavy chain; Plasma kallikrein light chain
UniProt Synonym Gene Names
UniProt Entry Name
KLKB1_MOUSE
UniProt Comments for KLKB1
KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.34; Protease
Cellular Component: extracellular space; extracellular region
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity
Biological Process: fibrinolysis; hemostasis; positive regulation of fibrinolysis; proteolysis; inflammatory response; blood coagulation; plasminogen activation
Research Articles on KLKB1
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Products associated with KLKB1 elisa kit
Pathways associated with KLKB1 elisa kit
Diseases associated with KLKB1 elisa kit
Organs/Tissues associated with KLKB1 elisa kit
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