Q6V1Q2.1
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UniProt Primary Accession #
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NCBI Official Full Name
RNA-directed RNA polymerase L
UniProt Protein Name
RNA-directed RNA polymerase L
UniProt Synonym Protein Names
Large structural protein; Replicase; TranscriptaseIncluding the following 3 domains:RNA-directed RNA polymerase (EC:2.7.7.48); mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56); mRNA guanylyltransferase (EC:2.7.7.-)
UniProt Synonym Gene Names
UniProt Entry Name
L_EBOZ5
UniProt Comments for L
Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The transcriptase stutters on a specific sequence, resulting on a cotranscriptional editing of the glycoprotein (GP) mRNA. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals ().
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