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L1/HPV18 recombinant protein :: papillomavirus type 18 L1 Recombinant Protein

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Catalog # MBS1265161
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.05 mg  /  $190 +1 FREE 8GB USB
  0.1 mg  /  $285 +1 FREE 8GB USB
  0.2 mg  /  $460 +1 FREE 8GB USB
  0.5 mg  /  $750 +1 FREE 8GB USB
  1 mg  /  $1,180 +1 FREE 8GB USB
SDS-PAGE
Product Name

papillomavirus type 18 L1 (L1/HPV18), Recombinant Protein

Also Known As

Recombinant Human papillomavirus type 18 L1 protein

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
358-533aa; Partial
Sequence Length
568
Sequence
GSIVTSDSQL FNKPYWLHKA QGHNNGVCWH NQLFVTVVDT TPSTNLTICA STQSPVPGQY DATKFKQYSR HVEEYDLQFI FQLCTITLTA DVMSYIHSMN SSILEDWNFG VPPPPTTSLV DTYRFVQSVA ITCQKDAAPA ENKDPYDKLK FWNVDLKEKF SLDLDQYPLG RKFLVQ
3D Structure
ModBase 3D Structure for P06794
Host
E Coli
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of L1/HPV18 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
L1/HPV18 recombinant protein
Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell.

L1/HPV18 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for L1/HPV18. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24.2kD
NCBI Official Full Name
L1 protein
NCBI Official Symbol
NCBI Protein Information
major capsid L1 protein
UniProt Protein Name
Major capsid protein L1
UniProt Gene Name
UniProt Entry Name
VL1_HPV18
UniProt Comments for L1/HPV18
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Product References and Citations for L1/HPV18 recombinant protein
Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987) Phylogenetic analysis of 48 papillomavirus types and 28 subtypes and variants a showcase for the molecular evolution of DNA viruses.Chan S.-Y., Bernard H.U., Ong C.K., Chan S.P., Birgit H., Delius H.J. Virol. 66:5714-5725(1992) Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens.Thierry F., Heard J.-M., Dartmann K., Yaniv M.J. Virol. 61:134-142(1987)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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