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LAG3 recombinant protein :: LAG3 / CD223 / Lymphocyte activation gene 3 Recombinant Protein

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Catalog # MBS2545158
Unit / Price
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  0.05 mg  /  $405 +1 FREE 8GB USB
  0.2 mg  /  $925 +1 FREE 8GB USB
SDS-PAGE
Product Name

LAG3 / CD223 / Lymphocyte activation gene 3, Recombinant Protein

Popular Item
Full Product Name

Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (Fc Tag)

Product Synonym Names
FDC
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
X51985 mRNA
3D Structure
ModBase 3D Structure for P18627
Host
Human Cells
Purity/Purification
> (3.0+91.0+3.1) % as determined by SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4
Predicted N Terminal
Val 29
Endotoxin
<1.0 EU per mug protein as determined by the LAL method.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of LAG3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
LAG3 recombinant protein
Background: LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

Description: A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of human IgG1 at the C-terminus.
Application Notes for LAG3 recombinant protein
The recombinant human LAG3 consists 660 amino acids and predicts a molecular mass of 72.3 kDa.

NCBI/Uniprot data below describe general gene information for LAG3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,103 Da
NCBI Official Full Name
lymphocyte activation gene 3 protein
NCBI Official Synonym Full Names
lymphocyte activating 3
NCBI Official Symbol
NCBI Official Synonym Symbols
CD223
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NCBI Protein Information
lymphocyte activation gene 3 protein
UniProt Protein Name
Lymphocyte activation gene 3 protein
UniProt Synonym Protein Names
Protein FDC; CD_antigen: CD223
UniProt Gene Name
UniProt Synonym Gene Names
FDC; LAG-3  [Similar Products]
NCBI Summary for LAG3
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
UniProt Comments for LAG3
LAG3: a cell surface receptor involved in lymphocyte activation and neural function. LAG3 expressed on neurons is a receptor that binds extracellular Alpha-synuclein fibrils (PFF) with high affinity, leading to its endocytosis. LAG3 facilitates the neuron-to-neuron spread of PFF and its associated neural toxicity. Binds to HLA class-II antigens. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Molecular Function: antigen binding; MHC class II protein binding
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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