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LBP protein

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Catalog # MBS584635
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LBP protein
Product Name

LBP, Protein

Popular Item
Full Product Name

LBP, Human, Peptide

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
LBP-peptid e is H2N-RVQGRW KVRKSFFK-C ONH2
OMIM
151990
Purity/Purification
>95%
Form/Format
Lyophilized, purified LBP-peptide from human LBP protein in PBS. The exact peptide amount is indicated on the label. Reconstitute the vial by pipetting sterile, endotoxin free phosphate buffered saline.
Species
Human
Preparation and Storage
Lyophilized product should be stored at 4 degree C. The stock solution should be stored in aliquots at -70 degree C in polypropylene tubes. LBP-peptide stock solution should never be thawed more than once. Repeated freeze and thaw cycles will cause loss of LBP-peptide activity. Under recommended storage conditions, product is stable for more than one year.
Other Notes
Small volumes of LBP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
LBP protein
Product Description: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into lipoproteins which neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. The LBP-peptide, amino acids 86-99, binds lipid A and neutralizes LPS in vivo and in vitro.
Application Notes for LBP protein
Application Use: For neutralization of biological activity dilutions have to be made according to the amounts protein to be inactivated. Further dilutions should be made by using protein stabilized phosphate buffered saline, pH 7. (Never use fresh serum/plasma). Be aware: endotoxin will bind LBP-peptide.
NCBI/Uniprot data below describe general gene information for LBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,384 Da
NCBI Official Full Name
Lipopolysaccharide-binding protein
NCBI Official Synonym Full Names
lipopolysaccharide binding protein
NCBI Official Symbol
NCBI Official Synonym Symbols
BPIFD2
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NCBI Protein Information
lipopolysaccharide-binding protein; LPS-binding protein; BPI fold containing family D, member 2
UniProt Protein Name
Lipopolysaccharide-binding protein
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
LBP_HUMAN
NCBI Summary for LBP
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
UniProt Comments for LBP
LBP: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: extracellular space; cell surface; extracellular region

Molecular Function: protein binding; lipopolysaccharide binding; receptor binding

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; detection of molecule of bacterial origin; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; defense response to Gram-negative bacterium; positive regulation of tumor necrosis factor production; leukocyte chemotaxis during inflammatory response; positive regulation of chemokine production; positive regulation of interleukin-8 production; lipopolysaccharide transport; defense response to Gram-positive bacterium; macrophage activation during immune response; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; acute-phase response; cellular defense response; innate immune response; opsonization; toll-like receptor 4 signaling pathway; positive regulation of macrophage activation
Product References and Citations for LBP protein
Bucki, R et al; Extracellular Gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J of Immunol. 2008, 181: 4936

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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