BC000482
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,809 Da
NCBI Official Full Name
Homo sapiens LIM domain binding 1, mRNA
NCBI Official Synonym Full Names
LIM domain binding 1
NCBI Protein Information
LIM domain-binding protein 1
UniProt Protein Name
LIM domain-binding protein 1
UniProt Synonym Protein Names
Carboxyl-terminal LIM domain-binding protein 2; CLIM-2; LIM domain-binding factor CLIM2; hLdb1; Nuclear LIM interactor
UniProt Synonym Gene Names
UniProt Entry Name
LDB1_HUMAN
UniProt Comments for LDB1
LDB1: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10q24-q25
Cellular Component: leading edge; nuclear chromatin; nucleus; protein complex; transcription factor complex
Molecular Function: enzyme binding; LIM domain binding; protein binding; protein homodimerization activity; transcription corepressor activity
Biological Process: negative regulation of erythrocyte differentiation; negative regulation of transcription, DNA-dependent; neuron differentiation; positive regulation of hemoglobin biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of focal adhesion formation; regulation of kinase activity; regulation of RNA elongation
Research Articles on LDB1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with LDB1 cdna clone
Diseases associated with LDB1 cdna clone
Organs/Tissues associated with LDB1 cdna clone
|