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LEP recombinant protein :: Leptin (LEP) Recombinant Protein

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Catalog # MBS9423109
Unit / Price
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  0.2 mg  /  $155 +1 FREE 8GB USB
  1 mg  /  $250 +1 FREE 8GB USB
LEP recombinant protein
Product Name

Leptin (LEP), Recombinant Protein

Full Product Name

Recombinant Human Leptin protein (LEP)

Product Synonym Names
LEP; OB; OBS
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U18915 mRNA
3D Structure
ModBase 3D Structure for P41159
Host
E Coli
Species Reactivity
Human
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Tag Info
Untagged
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of LEP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for LEP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16.0 kd
NCBI Official Full Name
leptin
NCBI Official Synonym Full Names
leptin
NCBI Official Symbol
NCBI Official Synonym Symbols
OB; OBS; LEPD
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NCBI Protein Information
leptin
UniProt Protein Name
Leptin
UniProt Synonym Protein Names
Obese protein; Obesity factor
Protein Family
UniProt Gene Name
NCBI Summary for LEP
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
UniProt Comments for LEP
leptin: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. Defects in LEP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the leptin family.

Protein type: Cell development/differentiation; Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: extracellular region; extracellular space

Molecular Function: hormone activity; peptide hormone receptor binding

Biological Process: adult feeding behavior; angiogenesis; energy reserve metabolic process; intestinal absorption; leptin-mediated signaling pathway; lipid metabolic process; negative regulation of appetite; negative regulation of autophagy; negative regulation of glucose import; placenta development; positive regulation of developmental growth; positive regulation of JAK-STAT cascade; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of T cell proliferation; positive regulation of TOR signaling pathway; prostaglandin secretion; regulation of angiogenesis; regulation of bone remodeling; regulation of cell cycle; regulation of endothelial cell proliferation; regulation of natural killer cell activation; regulation of natural killer cell mediated cytotoxicity; regulation of natural killer cell proliferation; regulation of nitric-oxide synthase activity; response to insulin stimulus; sexual reproduction; T cell differentiation; tyrosine phosphorylation of STAT protein

Disease: Leptin Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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