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LGALS4 recombinant protein :: Galectin-4 Recombinant Protein

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Catalog # MBS143568
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,235 +2 FREE 8GB USB
LGALS4 recombinant protein
Product Name

Galectin-4 (LGALS4), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Galectin-4

Product Synonym Names
LGALS4 Human; Galectin-4 Human Recombinant; Galectin-4; Gal-4; Lactose-binding lectin 4; L-36 lactose-binding protein; L36LBP; Antigen NY-CO-27; LGALS4; lectin galactoside-binding soluble 4; GAL4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
323
Sequence
MGSSHHHHHH SSGLVPRGSH MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR LSAFQRVDTL EIQGDVTLSY VQI
OMIM
602518
3D Structure
ModBase 3D Structure for P56470
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The LGALS4 protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT and 10% glycerol.
Sterile filtered colorless solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of LGALS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
LGALS4 recombinant protein
Description: Galectin-4 produced in E Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (1-323 a.a.) and having a molecular mass of 38.1kDa.Galectin-4 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. LGALS4 is in charge of intestinal inflammation via selective regulation of peripheral and mucosal T-cell cell cycle, in addition to cell death by apoptosis of T-cells by a pathway independent of the activation of caspases. LGALS4 blockade decreases TNF-alpha inhibitor induced T-cell death. LGALS4 decreases pro-inflammatory cytokine secretion including IL-6 & IL-17.
NCBI/Uniprot data below describe general gene information for LGALS4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
35,941 Da
NCBI Official Full Name
galectin-4
NCBI Official Synonym Full Names
lectin, galactoside-binding, soluble, 4
NCBI Official Symbol
LGALS4  [Similar Products]
NCBI Official Synonym Symbols
GAL4; L36LBP
  [Similar Products]
NCBI Protein Information
galectin-4; L-36 lactose-binding protein; antigen NY-CO-27; gal-4; galectin 4; lactose-binding lectin 4
UniProt Protein Name
Galectin-4
UniProt Synonym Protein Names
Antigen NY-CO-27; L-36 lactose-binding protein; L36LBP; Lactose-binding lectin 4
Protein Family
UniProt Gene Name
LGALS4  [Similar Products]
UniProt Synonym Gene Names
Gal-4; L36LBP  [Similar Products]
UniProt Entry Name
LEG4_HUMAN
NCBI Summary for LGALS4
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
UniProt Comments for LGALS4
galectin-4: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: plasma membrane; cytosol

Molecular Function: carbohydrate binding

Biological Process: cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withLGALS4 recombinant protein
 Reference Product  PubMed Publications
 CCNB1 recombinant protein  >1 publications with LGALS4 and CCNB1
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