NP_001034626.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
leukemia inhibitory factor isoform b
NCBI Official Synonym Full Names
leukemia inhibitory factor
NCBI Protein Information
leukemia inhibitory factor
UniProt Protein Name
Leukemia inhibitory factor
UniProt Synonym Protein Names
Differentiation-stimulating factor; D factor
UniProt Synonym Gene Names
UniProt Entry Name
LIF_MOUSE
UniProt Comments for LIF
LIF: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cytoplasm; extracellular region
Molecular Function: growth factor activity; leukemia inhibitory factor receptor binding; cytokine activity; receptor binding
Biological Process: transcription from RNA polymerase II promoter; maternal process involved in pregnancy; negative regulation of hormone secretion; leukemia inhibitory factor signaling pathway; tyrosine phosphorylation of Stat3 protein; decidualization; positive regulation of adrenocorticotropic hormone secretion; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; astrocyte differentiation; regulation of cell differentiation; negative regulation of meiosis; positive regulation of cell proliferation; positive regulation of macrophage differentiation; muscle morphogenesis; positive regulation of astrocyte differentiation; positive regulation of peptidyl-serine phosphorylation of STAT protein; organ regeneration; stem cell maintenance; stem cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; retina development in camera-type eye; neuron development; positive regulation of transcription from RNA polymerase II promoter; immune response; blood vessel remodeling; alveolus development; embryo implantation; lung development
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Products associated with LIF active protein
Pathways associated with LIF active protein
Diseases associated with LIF active protein
Organs/Tissues associated with LIF active protein
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