NP_031670.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,044 Da
NCBI Official Full Name
lysosome membrane protein 2
NCBI Official Synonym Full Names
scavenger receptor class B, member 2
NCBI Official Synonym Symbols
LGP85; Cd36l2; LIMP-2; MLGP85; LIMP II; 9330185J12Rik [Similar Products]
NCBI Protein Information
lysosome membrane protein 2
UniProt Protein Name
Lysosome membrane protein 2
UniProt Synonym Protein Names
85 kDa lysosomal membrane sialoglycoprotein; LGP85; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2
UniProt Synonym Gene Names
NCBI Summary for LIMP-2 / SCARB2 / CD36L2
This gene encodes a CD36-like type III transmembrane glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]
UniProt Comments for LIMP-2 / SCARB2 / CD36L2
SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 5|5 E2
Cellular Component: focal adhesion; lysosomal lumen; lysosomal membrane; membrane
Molecular Function: enzyme binding
Biological Process: protein targeting to lysosome
Research Articles on LIMP-2 / SCARB2 / CD36L2
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Pathways associated with LIMP-2 / SCARB2 / CD36L2 recombinant protein
Diseases associated with LIMP-2 / SCARB2 / CD36L2 recombinant protein
Organs/Tissues associated with LIMP-2 / SCARB2 / CD36L2 recombinant protein
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