NP_002791.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,328 Da
NCBI Official Full Name
proteasome subunit beta type-9 proprotein
NCBI Official Synonym Full Names
proteasome (prosome, macropain) subunit, beta type, 9
NCBI Protein Information
proteasome subunit beta type-9; macropain chain 7; proteasome chain 7; proteasome-related gene 2; proteasome subunit beta 6i; proteasome subunit beta-1i; low molecular mass protein 2; proteasome catalytic subunit 1i; large multifunctional peptidase 2; really interesting new gene 12 protein; multicatalytic endopeptidase complex chain 7; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
UniProt Protein Name
Proteasome subunit beta type-9
UniProt Synonym Protein Names
Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 protein
UniProt Synonym Gene Names
UniProt Entry Name
PSB9_HUMAN
NCBI Summary for LMP2 / PSMB9
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]
UniProt Comments for LMP2 / PSMB9
PSMB9: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Belongs to the peptidase T1B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Proteasome complex; Nuclear receptor co-regulator; EC 3.4.25.1
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nucleoplasm; proteasome complex; proteasome core complex; cytoplasm; cytosol
Molecular Function: threonine endopeptidase activity; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on LMP2 / PSMB9
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Products associated with LMP2 / PSMB9 elisa kit
Pathways associated with LMP2 / PSMB9 elisa kit
Diseases associated with LMP2 / PSMB9 elisa kit
Organs/Tissues associated with LMP2 / PSMB9 elisa kit
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