NP_002326.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
179,145 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 5 isoform 1
NCBI Official Synonym Full Names
LDL receptor related protein 5
NCBI Official Synonym Symbols
HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2 [Similar Products]
NCBI Protein Information
low-density lipoprotein receptor-related protein 5
UniProt Protein Name
Low-density lipoprotein receptor-related protein 5
UniProt Synonym Gene Names
NCBI Summary for LRP5
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for LRP5
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (). Required for posterior patterning of the epiblast during gastrulation ().
Research Articles on LRP5
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Products associated with LRP5 antibody pair kit
Pathways associated with LRP5 antibody pair kit
Diseases associated with LRP5 antibody pair kit
Organs/Tissues associated with LRP5 antibody pair kit
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