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LRRC8A cdna clone

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Catalog # MBS1275952
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $700 +1 FREE 8GB USB
LRRC8A cdna clone
Product Name

LRRC8A, cDNA Clone

Full Product Name


Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1275952 Technical Datasheet
atgattccgg tgacagagct ccgctacttt gcggacacgc agccagcata ccggatcctg aagccgtggt gggatgtgtt cacagactac atctctatcg tcatgctgat gattgccgtc ttcgggggga cgctgcaggt cacccaagac aagatgatct gcctgccttg taagtgggtc accaaggact cctgcaatga ttcgttccgg ggctgggcag cccctggccc ggagcccacc taccccaact ccaccattct gccgacccct gacacgggcc ccacaggcat caagtatgac ctggaccggc accagtacaa ctacgtggac gctgtgtgct atgagaaccg actgcactgg tttgccaagt acttccccta cctggtgctt ctgcacacgc tcatcttcct ggcctgcagc aacttctggt tcaaattccc gcgcaccagc tcgaagctgg agcactttgt gtctatcctg ctgaagtgct tcgactcgcc ctggaccacg agggccctgt cggagacagt ggtggaggag agcgacccca agccggcctt cagcaagatg aatgggtcca tggacaaaaa gtcatcgacc gtcagtgagg acgtggaggc caccgtgccc atgctgcagc ggaccaagtc acggatcgag cagggtatcg tggaccgctc agagacgggc gtgctggaca agaaggaggg ggagcaagcc aaggcgctgt ttgagaaggt gaagaagttc cggacccatg tggaggaggg ggacattgtg taccgcctct acatgcggca gaccatcatc aaggtgatca agttcatcct catcatctgc tacaccgtct actacgtgca caacatcaag ttcgacgtgg actgcaccgt ggacattgag agcctgacgg gctaccgcac ctaccgctgt gcccaccccc tggccacact cttcaagatc ctggcgtcct tctacatcag cctagtcatc ttctacggcc tcatctgcat gtatacactg tggtggatgc tacggcgctc cctcaagaag tactcgtttg agtcgatccg tgaggagagc agctacagcg acatccccga cgtcaagaac gacttcgcct tcatgctgca cctcattgac caatacgacc cgctctactc caagcgcttc gccgtcttcc tgtcggaggt gagtgagaac aagctgcggc agctgaacct caacaacgag tggacgctgg acaagctccg gcagcggctc accaagaacg cgcaggacaa gctggagctg cacctgttca tgctcagtgg catccctgac actgtgtttg acctggtgga gctggaggtc ctcaagctgg agctgatccc cgacgtgacc atcccgccca gcattgccca gctcacgggc ctcaaggagc tgtggctcta ccacacagcg gccaagattg aagcgcccgc gctggccttc ctgcgcgaga acctgcgggc gctgcacatc aagttcaccg acatcaagga gatcccgctg tggatctata gcctgaagac actggaggag ctgcacctga cgggcaacct gagcgcggag aacaaccgct acatcgtcat cgacgggctg cgggagctca aacgcctcaa ggtgctgcgg ctcaagagca acctaagcaa gctgccacag gtggtcacag atgtgggcgt gcacctgcag aagctgtcca tcaacaatga gggcaccaag ctcatcgtcc tcaacagcct caagaagatg gcgaacctga ctgagctgga gctgatccgc tgtgacctgg agcgcatccc ccactccatc ttcagcctcc acaacctgca ggagattgac ctcaaggaca acaacctcaa gaccatcgag gagatcatca gcttccagca cctgcaccgc ctcacctgcc ttaagctgtg gtacaaccac atcgcctaca tccccatcca gatcggcaac ctcaccaacc tggagcgcct ctacctgaac cgcaacaaga tcgagaagat ccccacccag ctcttctact gccgcaagct gcgctacctg gacctcagcc acaacaacct gaccttcctc cctgccgaca tcggcctcct gcagaacctc cagaacctag ccatcacggc caaccggatc gagacgctcc ctccggagct cttccagtgc cggaagctgc gggccctgca cctgggcaac aacgtgctgc agtcactgcc ctccagggtg ggcgagctga ccaacctgac gcagatcgag ctgcggggca accggctgga gtgcctgcct gtggagctgg gcgagtgccc actgctcaag cgcagcggct tggtggtgga ggaggacctg ttcaacacac tgccacccga ggtgaaggag cggctgtgga gggctgacaa ggagcaggcc tga
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ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of LRRC8A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for LRRC8A. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
94,199 Da
NCBI Official Full Name
Homo sapiens leucine rich repeat containing 8 family, member A, mRNA
NCBI Official Synonym Full Names
leucine rich repeat containing 8 family member A
NCBI Official Symbol
LRRC8A  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
volume-regulated anion channel subunit LRRC8A
UniProt Protein Name
Volume-regulated anion channel subunit LRRC8A
UniProt Synonym Protein Names
Leucine-rich repeat-containing protein 8A; Swelling protein 1
UniProt Gene Name
LRRC8A  [Similar Products]
UniProt Synonym Gene Names
KIAA1437; LRRC8; SWELL1  [Similar Products]
UniProt Entry Name
NCBI Summary for LRRC8A
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for LRRC8A
LRRC8A: Involved in B-cell development. Required for the pro-B cell to pre-B cell transition. Defects in LRRC8A are the cause of agammaglobulinemia type 5 (AGM5). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function: anion channel activity; protein binding; volume-sensitive anion channel activity

Biological Process: anion transport; cell volume homeostasis; pre-B cell differentiation; response to osmotic stress

Disease: Agammaglobulinemia 5, Autosomal Dominant
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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