NP_665874.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,567 Da
NCBI Official Full Name
leukotriene C4 synthase
NCBI Official Synonym Full Names
leukotriene C4 synthase
NCBI Protein Information
leukotriene C4 synthase; LTC4 synthase
UniProt Protein Name
Leukotriene C4 synthase
UniProt Synonym Protein Names
Leukotriene-C(4) synthase
UniProt Synonym Gene Names
UniProt Entry Name
LTC4S_HUMAN
NCBI Summary for LTC4
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
UniProt Comments for LTC4
LTC4S: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency). LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. Belongs to the MAPEG family.
Protein type: Membrane protein, multi-pass; Lyase; Nuclear envelope; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Endoplasmic reticulum; EC 4.4.1.20
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane; nuclear envelope
Molecular Function: protein binding; glutathione transferase activity; leukotriene-C4 synthase activity; enzyme activator activity; glutathione peroxidase activity; lipid binding
Biological Process: leukotriene biosynthetic process; positive regulation of catalytic activity; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process
Disease: Leukotriene C4 Synthase Deficiency
Research Articles on LTC4
Precautions
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Products associated with LTC4 elisa kit
Diseases associated with LTC4 elisa kit
Organs/Tissues associated with LTC4 elisa kit
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