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anti-M-CSF Receptor antibody :: Rabbit M-CSF Receptor (Ab-809) Antibody

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Catalog # MBS002565
Unit / Price
  0.05 mL  /  $270 +1 FREE 8GB USB
  0.1 mL  /  $445 +1 FREE 8GB USB
anti-M-CSF Receptor antibody
Product Name

M-CSF Receptor (Ab-809), Antibody

Also Known As

Rabbit M-CSF Receptor (Ab-809) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
972
Chromosome Location
Chromosome: 5; NC_000005.9 (149432854..149492935, complement). Location: 5q32
OMIM
164770
3D Structure
ModBase 3D Structure for P07333
Host
Rabbit
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-M-CSF Receptor antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-M-CSF Receptor antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for M-CSF Receptor. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,984 Da
NCBI Official Full Name
macrophage colony-stimulating factor 1 receptor
NCBI Official Synonym Full Names
colony stimulating factor 1 receptor
NCBI Official Symbol
CSF1R  [Similar Products]
NCBI Official Synonym Symbols
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
  [Similar Products]
NCBI Protein Information
macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog
UniProt Protein Name
Macrophage colony-stimulating factor 1 receptor
UniProt Synonym Protein Names
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
UniProt Gene Name
CSF1R  [Similar Products]
UniProt Synonym Gene Names
FMS; CSF-1-R; CSF-1R; M-CSF-R  [Similar Products]
UniProt Entry Name
CSF1R_HUMAN
NCBI Summary for M-CSF Receptor
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
UniProt Comments for M-CSF Receptor
CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Oncoprotein; Kinase, protein; EC 2.7.10.1; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding

Biological Process: regulation of bone resorption; macrophage differentiation; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; monocyte differentiation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; multicellular organismal development; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; intercellular junction maintenance; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration

Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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