• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MAML1 peptide :: MAML1 / Mastermind Peptide

Scan QR to view Datasheet
Catalog # MBS426189
Unit / Price
Scan QR to view Datasheet
  0.1 mg  /  $190 +1 FREE 8GB USB
MAML1 peptide
Product Name

MAML1 / Mastermind, Peptide

Full Product Name

MAML1 / Mastermind Immunizing Peptide

Product Synonym Names
MAML1; mastermind-like 1 (Drosophila); Mam1; Mam-1; KIAA0200; mastermind homolog; mastermind-like 1; MAML1 / Mastermind
Product Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
VLPTCPMAEF ALPR
OMIM
605424
Species Reactivity
Human, Mouse
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of MAML1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MAML1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,054 Da
NCBI Official Full Name
mastermind-like protein 1
NCBI Official Synonym Full Names
mastermind like transcriptional coactivator 1
NCBI Official Symbol
MAML1  [Similar Products]
NCBI Official Synonym Symbols
Mam1; Mam-1
  [Similar Products]
NCBI Protein Information
mastermind-like protein 1
UniProt Protein Name
Mastermind-like protein 1
Protein Family
UniProt Gene Name
MAML1  [Similar Products]
UniProt Synonym Gene Names
Mam-1  [Similar Products]
UniProt Entry Name
MAML1_HUMAN
NCBI Summary for MAML1
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
UniProt Comments for MAML1
MAML1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus

Molecular Function: peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity

Biological Process: activation of Notch receptor target transcription factor; myoblast differentiation; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transcription initiation from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000