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MAP1LC3B cdna clone

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Catalog # MBS1275159
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
MAP1LC3B cdna clone
Product Name

MAP1LC3B, cDNA Clone

Popular Item
Full Product Name

MAP1LC3B cDNA Clone

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGAGTGAGC TCATCAAGAT AATTAGAAGG CGCTTACAGC TCAATGCTAA TCAGGCCTTC TTCCTGTTGG TGAACGGACA CAGCATGGTC AGCGTCTCCA CACCAATCTC AGAGGTGTAT GAGAGTGAGA AAGATGAAGA TGGATTCCTG TACATGGTCT ATGCCTCCCA GGAGACGTTC GGGATGAAAT TGTCAGTGTA A
OMIM
609604
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of MAP1LC3B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MAP1LC3B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,688 Da
NCBI Official Full Name
Homo sapiens microtubule-associated protein 1 light chain 3 beta, mRNA
NCBI Official Synonym Full Names
microtubule associated protein 1 light chain 3 beta
NCBI Official Symbol
MAP1LC3B  [Similar Products]
NCBI Official Synonym Symbols
LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3
  [Similar Products]
NCBI Protein Information
microtubule-associated proteins 1A/1B light chain 3B
UniProt Protein Name
Microtubule-associated proteins 1A/1B light chain 3B
UniProt Synonym Protein Names
Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta
UniProt Gene Name
MAP1LC3B  [Similar Products]
UniProt Synonym Gene Names
MAP1ALC3; MAP1A/MAP1B LC3 B  [Similar Products]
UniProt Entry Name
MLP3B_HUMAN
NCBI Summary for MAP1LC3B
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
UniProt Comments for MAP1LC3B
LC3B: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Recruits proteins such as SQSTM1 and NBR1 to the autophagosome.

Protein type: Ubiquitin-like modifier; Vesicle; Microtubule-binding; Autophagy

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: autophagic vacuole; axoneme; cytosol; intracellular; mitochondrion

Molecular Function: microtubule binding; protein binding; ubiquitin protein ligase binding

Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with MAP1LC3B cdna clone
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