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anti-MAP4K4 antibody :: Rabbit NIK (CT) Antibody

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Catalog # MBS194123
Unit / Price
  0.1 mg  /  $400 +1 FREE 8GB USB
anti-MAP4K4 antibody
Product Name

NIK (CT) (MAP4K4), Antibody

Also Known As

Anti-NIK (CT) Antibody

Product Synonym Names
Anti-NIK (CT); NIK (CT)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (102314488..102511152). Location: 2q11.2-q12
OMIM
604666
3D Structure
ModBase 3D Structure for O95819
Host
Rabbit
Specificity
Anti-NIK (CT) [Rabbit antibody to peptide corresponding to aa 932-947 of human NIK.]
This antibody recognizes human NIK.
Form/Format
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
Antigen
Peptide corresponding to aa 931- 947 of human NIK.
Stabilizer
None
Preservatives
0.02% sodium azide.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-MAP4K4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MAP4K4 antibody
Nuclear factor kappa B (NF- kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF- kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF alpha , LPS, and mitogens. A serine/threonine protein kinase which mediates NF- kappa B activation by IL-1, TNF alpha , and CD95 has been identified and designated NIK (for NF- kappa B inducing kinase). NIK is an activator of I kappa B kinase alpha and beta (IKK alpha and IKK beta ). Therefore, NIK is a key molecule in the NF- kappa B signaling pathway leading to the expression of a variety of gene products in response to pro-inflammatory cytokines and bacterial products.
Applications Tested/Suitable for anti-MAP4K4 antibody
Immunoblot
Application Notes for anti-MAP4K4 antibody
Immunoblotting: use at 1:500 dilution.
Positive control: Whole cell lysate of 293 cells.
NCBI/Uniprot data below describe general gene information for MAP4K4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
142,101 Da[Similar Products]
NCBI Official Full Name
NIK
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase kinase 4
NCBI Official Symbol
MAP4K4  [Similar Products]
NCBI Official Synonym Symbols
HGK; NIK; MEKKK4; FLH21957; FLJ10410; FLJ20373; FLJ90111; KIAA0687
  [Similar Products]
NCBI Protein Information
mitogen-activated protein kinase kinase kinase kinase 4; OTTHUMP00000207902; OTTHUMP00000207903; OTTHUMP00000207971; OTTHUMP00000207972; OTTHUMP00000207973; OTTHUMP00000207974; MEK kinase kinase 4; nck-interacting kinase; HPK/GCK-like kinase HGK; Ste20 group protein kinase HGK; MAPK/ERK kinase kinase kinase 4; hepatocyte progenitor kinase-like/germinal center kinase-like kinase
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase kinase 4
UniProt Synonym Protein Names
HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase
UniProt Gene Name
MAP4K4  [Similar Products]
UniProt Synonym Gene Names
HGK; KIAA0687; NIK  [Similar Products]
UniProt Entry Name
M4K4_HUMAN
NCBI Summary for MAP4K4
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
UniProt Comments for MAP4K4
HGK: a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 2q11.2-q12

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: microvillus biogenesis; regulation of catalytic activity; regulation of JNK cascade; protein amino acid phosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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