BC066645
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,488 Da
NCBI Official Full Name
Homo sapiens methionine adenosyltransferase II, beta, mRNA
NCBI Official Synonym Full Names
methionine adenosyltransferase 2B
NCBI Official Synonym Symbols
TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999 [Similar Products]
NCBI Protein Information
methionine adenosyltransferase 2 subunit beta
UniProt Protein Name
Methionine adenosyltransferase 2 subunit beta
UniProt Synonym Protein Names
Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
UniProt Synonym Gene Names
UniProt Entry Name
MAT2B_HUMAN
NCBI Summary for MAT2B
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
UniProt Comments for MAT2B
MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid; Transferase
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: cytosol; intracellular; methionine adenosyltransferase complex; nucleus
Molecular Function: enzyme binding; methionine adenosyltransferase regulator activity; protein binding
Biological Process: methylation; S-adenosylmethionine biosynthetic process
Research Articles on MAT2B
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Pathways associated with MAT2B cdna clone
Diseases associated with MAT2B cdna clone
Organs/Tissues associated with MAT2B cdna clone
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