• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Mbp native protein :: Myelin Basic Protein >90% Pure Native Protein

Scan QR to view Datasheet
Catalog # MBS318337
Unit / Price
Scan QR to view Datasheet
  1 mg  /  $315 +1 FREE 8GB USB
Mbp native protein
Product Name

Myelin Basic Protein >90% Pure (Mbp), Native Protein

Full Product Name

Myelin Basic Protein

Product Synonym Names
Contains 18.5kDa and 14.2kDa isoforms and their dimers (13.5% SDS-PAGE non-reducing conditions)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 18; NC_005117.2 (78943608..79057329). Location: 18q
3D Structure
ModBase 3D Structure for P02688
Host
Human brain
Specificity
Myelin Basic Protein >90% Pure
Purity/Purification
>95% pure (SDS-PAGE)
Form/Format
Purified, Lyophilized
Reconstitute with 10mM HCl
Inactivation
Not applicable
Buffer
Not applicable
Preservative
No
Lyophilized
Yes
Warnings
Blood sample from the tissue donor tested negative for HIV 1, HIV 2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially in
Preparation and Storage
Store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Mbp native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Mbp native protein
Application Notes for Mbp native protein
Immunoreactivity is checked using polyclonal and monoclonal antibodies against MBP. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not
NCBI/Uniprot data below describe general gene information for Mbp. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,502 Da[Similar Products]
NCBI Official Full Name
myelin basic protein isoform 4
NCBI Official Synonym Full Names
myelin basic protein
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
Golli-Mbp; myelin basic protein; MBP S; myelin basic protein S; myelin basic protein Golli-mbp; Golli-Mbp; myelin basic protein; myelin basic protein S
UniProt Protein Name
Myelin basic protein S
Protein Family
UniProt Gene Name
UniProt Entry Name
MBP_RAT
NCBI Summary for Mbp
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq]
UniProt Comments for Mbp
Function: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane

Subunit structure: Homodimer

Subcellular location: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin.

Tissue specificity: Found in both the central and the peripheral nervous system.

Post-translational modification: As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated.

Sequence similarities: Belongs to the myelin basic protein family.
Product References and Citations for Mbp native protein
• Diebler, G.E., (1972), Preparative Biochemistry, 2(2) 139-165.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with Mbp native protein
 Products by Pathway  Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000