NP_058673.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Official Synonym Symbols
NCBI Protein Information
melanocortin receptor 4
UniProt Protein Name
Melanocortin receptor 4
UniProt Synonym Gene Names
UniProt Entry Name
MC4R_MOUSE
NCBI Summary for Mc4r
This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]
UniProt Comments for Mc4r
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Cellular Component: membrane; cell; integral to membrane; plasma membrane; nucleus
Molecular Function: G-protein coupled receptor activity; neuropeptide binding; protein binding; signal transducer activity; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity; ubiquitin protein ligase binding
Biological Process: G-protein coupled receptor protein signaling pathway; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; regulation of metabolic process; signal transduction; response to insulin stimulus
Research Articles on Mc4r
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Pathways associated with Mc4r recombinant protein
Diseases associated with Mc4r recombinant protein
Organs/Tissues associated with Mc4r recombinant protein
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