BC080656
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,932 Da
NCBI Official Full Name
Homo sapiens minichromosome maintenance complex component 8, mRNA
NCBI Official Synonym Full Names
minichromosome maintenance 8 homologous recombination repair factor
NCBI Protein Information
DNA helicase MCM8
UniProt Protein Name
DNA helicase MCM8
UniProt Synonym Protein Names
Minichromosome maintenance 8
UniProt Synonym Gene Names
UniProt Entry Name
MCM8_HUMAN
NCBI Summary for MCM8
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
UniProt Comments for MCM8
MCM8: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. Belongs to the MCM family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 20p12.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: DNA replication; female gamete generation; G1/S transition of mitotic cell cycle; male gamete generation; response to DNA damage stimulus
Disease: Premature Ovarian Failure 10
Research Articles on MCM8
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Pathways associated with MCM8 cdna clone
Diseases associated with MCM8 cdna clone
Organs/Tissues associated with MCM8 cdna clone
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