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MCP 4 recombinant protein :: Monocyte Chemotactic Protein-4 Recombinant Protein

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Catalog # MBS144164
Unit / Price
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  0.001 mg  /  $140 +1 FREE 8GB USB
  0.005 mg  /  $205 +1 FREE 8GB USB
  0.05 mg  /  $1,220 +1 FREE 8GB USB
MCP 4 recombinant protein
Product Name

Monocyte Chemotactic Protein-4 (MCP 4), Recombinant Protein

Full Product Name

Recombinant Human Monocyte Chemotactic Protein-4 (CCL13), His Tag

Product Synonym Names
MCP 4 Human, His; Monocyte Chemotactic Protein-4 Human Recombinant (CCL13), His-Tag; CKb10; MCP-4; NCC-1; NCC1; SCYA1; SCYL1; CK-beta-10; Small-inducible cytokine A13; MCP 4, His
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MQPDALNVPS TCCFTFSSKK ISLQRLKSYV ITTSRCPQKA VIFRTKLGKE ICADPKEKWV QNYMKHLGRK .AHTLKT
OMIM
601391
3D Structure
ModBase 3D Structure for Q99616
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The His Tag 0.25mg/ml MCP4 protein solution contains PBS pH-7.4, 1mM DTT, 0.1M NaCl and 10% glycerol.
Sterile Filtered colorless clear solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
Other Notes
Small volumes of MCP 4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MCP 4 recombinant protein
Description: MCP4 Human Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 96 amino acids (24-98) and having a molecular mass of 10.8 kDa. The MCP-4 is fused to 21 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: CCL13 chemokine is part of the CC chemokine family (TARC). CCL13 protein induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. CCL13 is induced by the inflammatory cytokines IL1 & TNFA.
NCBI/Uniprot data below describe general gene information for MCP 4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,986 Da
NCBI Official Full Name
C-C motif chemokine 13
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 13
NCBI Official Symbol
CCL13  [Similar Products]
NCBI Official Synonym Symbols
NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13
  [Similar Products]
NCBI Protein Information
C-C motif chemokine 13; CK-beta-10; monocyte chemoattractant protein 4; monocyte chemotactic protein 4; new CC chemokine 1; small inducible cytokine subfamily A (Cys-Cys), member 13; small-inducible cytokine A13
UniProt Protein Name
C-C motif chemokine 13
UniProt Synonym Protein Names
CK-beta-10; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4; NCC-1; Small-inducible cytokine A13Cleaved into the following 3 chains:C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain
UniProt Gene Name
CCL13  [Similar Products]
UniProt Synonym Gene Names
MCP4; NCC1; SCYA13; MCP-4  [Similar Products]
UniProt Entry Name
CCL13_HUMAN
NCBI Summary for MCP 4
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
UniProt Comments for MCP 4
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: extracellular space

Molecular Function: chemokine activity; receptor binding

Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; immune response; cytoskeleton organization and biogenesis; chemotaxis; signal transduction; inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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