• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Melt peptide :: Melittin Peptide

Scan QR to view Datasheet
Catalog # MBS659880
Unit / Price
  1 mg  /  $380 +1 FREE 8GB USB
Melt peptide
Product Name

Melittin (Melt), Peptide

Popular Item
Also Known As

Melittin

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: LG4; NC_007073.3 (9255700..9257194). Location: chromosome: LG4
3D Structure
ModBase 3D Structure for P01501
Host
Synthetic peptide
Purity/Purification
96.49%
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Molecular Formula
C131H229N39O31
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of Melt peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Melt peptide
NCBI/Uniprot data below describe general gene information for Melt. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
melittin
NCBI Official Synonym Full Names
melittin<
NCBI Official Symbol
NCBI Official Synonym Symbols
GB10355
  [Similar Products]
NCBI Protein Information
melittin; allergen Api m 3; allergen Api m III
UniProt Protein Name
Melittin
UniProt Synonym Protein Names
Allergen Api m 3; Allergen Api m III
Protein Family
UniProt Gene Name
UniProt Entry Name
MEL_APIME
UniProt Comments for Melt
Function: Melittin: Main toxin of bee venom with strong hemolytic activity. Forms a pore in the cell membrane by inserting into lipid bilayers in an alpha-helical conformation and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. It increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange. It acts synergistically with phospholipase A2. Ref.3Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin. Ref.3

Subunit structure: Monomer and homotetramer.

Subcellular location: Secreted. Target cell membrane. Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey.

Tissue specificity: Expressed by the venom gland.

Allergenic properties: Causes an allergic reaction in human.

Toxic dose: LC50 is 2.7 µg/ml against killifish. Ref.7

Miscellaneous: N-formyl-melittin major has 80% of the activity of melittin.Melittin: The secretion of this protein into venom follows a seasonal pattern. This variation is synchronized with phospholipase A2 variation, i.e. their production increase in the same months.Melittin-S: The secretion of this protein into venom follows a seasonal pattern, the maximum secretion occurring during the (southern) winter months.

Sequence similarities: Belongs to the melittin family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000