NP_001171623.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,291 Da
NCBI Official Full Name
matrix extracellular phosphoglycoprotein isoform a
NCBI Official Synonym Full Names
matrix extracellular phosphoglycoprotein
NCBI Official Synonym Symbols
NCBI Protein Information
matrix extracellular phosphoglycoprotein
UniProt Protein Name
Matrix extracellular phosphoglycoprotein
UniProt Synonym Protein Names
Osteoblast/osteocyte factor 45; OF45
UniProt Synonym Gene Names
UniProt Entry Name
MEPE_HUMAN
NCBI Summary for MEPE
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for MEPE
MEPE: Promotes renal phosphate excretion and modulates mineralization. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: proteinaceous extracellular matrix
Molecular Function: protein binding; extracellular matrix structural constituent
Biological Process: negative regulation of bone mineralization; biomineral formation; regulation of bone remodeling; skeletal development
Research Articles on MEPE
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Products associated with MEPE sirna
Diseases associated with MEPE sirna
Organs/Tissues associated with MEPE sirna
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