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anti-MER/SKY antibody :: MER/SKY Antibody

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Catalog # MBS853167
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

MER/SKY, Antibody

Popular Item
Also Known As

MER/SKY (Phospho-Tyr749/681) Antibody

Product Synonym Names
C-mer; EC; kinase Mer; MERK; MERTK; proto-oncogene tyrosine-protein kinase MER precursor; receptor tyrosine kinase MerTK
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3D Structure
ModBase 3D Structure for Q12866
Species Reactivity
Human, Mouse, Rat
MER/SKY (Phospho-Tyr749/681) antibody detects endogenous levels of MER/SKY only when phosphorylated at tyrosine 749/681.
Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
The antiserum was produced against synthesized phosphopeptide derived from human MER/SKY around the phosphorylation site of tyrosine 749/681 (K-I-YP-S-G).
All Sites
Human: Tyr749/681
Mouse: Tyr744/671
Rat: Tyr744/671
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-MER/SKY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MER/SKY antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MER/SKY antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Testing Data of anti-MER/SKY antibody
anti-MER/SKY antibody Testing Data image
Immunohistochemistry (IHC) of anti-MER/SKY antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MER/SKY (Phospho-Tyr749/681) antibody. Western blot analysis of extracts from 3T3 cells, treated with EGF (200ng/ml, 5mins), using MER/SKY (Phospho-Tyr749/681) antibody.
anti-MER/SKY antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MER/SKY. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
110,249 Da
NCBI Official Full Name
tyrosine-protein kinase Mer
NCBI Official Synonym Full Names
MER proto-oncogene, tyrosine kinase
NCBI Official Symbol
MERTK  [Similar Products]
NCBI Official Synonym Symbols
MER; RP38; c-Eyk; c-mer; Tyro12
  [Similar Products]
NCBI Protein Information
tyrosine-protein kinase Mer
UniProt Protein Name
Tyrosine-protein kinase Mer
UniProt Synonym Protein Names
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
UniProt Gene Name
MERTK  [Similar Products]
UniProt Synonym Gene Names
NCBI Summary for MER/SKY
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
UniProt Comments for MER/SKY
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Product References and Citations for anti-MER/SKY antibody
Graham D.K., Cell Growth Differ. 5:647-657(1994). Gal A., Nat. Genet. 26:270-271(2000). Hillier L.W., Nature 434:724-731(2005).

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