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MET recombinant protein :: Met Proto-Oncogene Recombinant Protein

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Catalog # MBS144821
Unit / Price
  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $205 +1 FREE 8GB USB
  0.1 mg  /  $1,030 +1 FREE 8GB USB
MET recombinant protein
Product Name

Met Proto-Oncogene, Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Met Proto-Oncogene

Product Synonym Names
MET Human; Met Proto-Oncogene Human Recombinant
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
DSDISSPLLQ NTVHIDLSAL NPELVQAVQH VVIGPSSLIV HFNEVIGRGH FGCVYHGTLL DNDGKKIHCA VKSLNRITDI GEVSQFLTEG IIMKDFSHPN VLSLLGICLR SEGSPLVVLP YMKHGDLRNF IRNETHNPTV KDLIGFGLQV AKGMKYLASK KFVHRDLAAR NCMLDEKFTV KVADFGLARD MYDKEYYSVH NKTGAKLPVK WMALESLQTQ KFTTKSDVWS FGVLLWELMT RGAPPYPDVN TFDITVYLLQ GRRLLQPEYC PDPLYEVMLK CWHPKAEMRP SFSELVSRIS AIFSTFI.
OMIM
114550
3D Structure
ModBase 3D Structure for P08581
Host
Insect Cells
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
MET protein (1mg/ml) is supplied in 50mM Tris, 300mM NaCl, 10% Glycerol, pH 7.5.
Sterile Filtered clear colorless solution.
Preparation and Storage
Store at 4 degree C if entire vial will be lIsed within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time .
Please avoid freeze thaw cycles,
Other Notes
Small volumes of MET recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MET recombinant protein
Description: Met Proto-Oncogene Human Recombinant produced in Insect cells amino acids 1039-1345, having a molecular weight of 34.6kDa.c-MET is purified by proprietary chromatographic techniques.

Introduction: Mesenchymal epithelial transition factor (c-MET) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for c-MET is HGF (hepatocyte growth factor), which is a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, c-MET protein expression is limited to stem and progenitor cells and is required for wound healing and hepatocyte regeneration. In the embryo, c-MET receptors are expressed on cells of epithelial origin, which are vital for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abnormal activation of the HGF/MET pathway leads to a variety of cancers. c-MET mutation is linked with a poor prognosis since it can trigger tumor growth, angiogenesis and metastasis.
NCBI/Uniprot data below describe general gene information for MET. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85,745 Da
NCBI Official Full Name
hepatocyte growth factor receptor isoform b
NCBI Official Synonym Full Names
MET proto-oncogene, receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
HGFR; AUTS9; RCCP2; c-Met
  [Similar Products]
NCBI Protein Information
hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met
UniProt Protein Name
Hepatocyte growth factor receptor
UniProt Synonym Protein Names
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
UniProt Gene Name
UniProt Synonym Gene Names
HGF receptor; SF receptor  [Similar Products]
UniProt Entry Name
MET_HUMAN
NCBI Summary for MET
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MET
Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, integral; Oncoprotein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; Met family

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: cell surface; integral to plasma membrane; integral to membrane; plasma membrane; extracellular region; basal plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; hepatocyte growth factor receptor activity; protein phosphatase binding; ATP binding

Biological Process: axon guidance; skeletal muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; myoblast proliferation; protein amino acid autophosphorylation; myotube differentiation; muscle cell migration; hepatocyte growth factor receptor signaling pathway; liver development; glucose homeostasis; signal transduction; cell proliferation; cell surface receptor linked signal transduction; positive chemotaxis; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; brain development; endothelial cell morphogenesis; placenta development

Disease: Hepatocellular Carcinoma; Renal Cell Carcinoma, Papillary, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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