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MIP-3 beta active protein :: MIP-3b Active Protein

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Catalog # MBS506038
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $450 +1 FREE 8GB USB
  0.5 mg  /  $1,730 +2 FREE 8GB USB
  1 mg  /  $2,825 +3 FREE 8GB USB
Gel Data
Product Name

MIP-3b (MIP-3 beta), Active Protein

Popular Item
Full Product Name

Human MIP-3b (CCL19)

Product Synonym Names
Macrophage Inflammatory Protein-3 beta; CCL19; SCYA19; ELC; Exodus-3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
OMIM
U77180 mRNA
3D Structure
ModBase 3D Structure for Q99731
Host
E Coli
Purity/Purification
>=95
Form/Format
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing
0.1% Trifluoroacetic Acid (TFA)
Species
Human
Bioactivity Assay
bioactive protein but no acceptaince criteria limits established
Reconstitution
Sterile water at 0.1 mg/mL
Acceptance Criteria LAL (EUs/ug)
<=1.00
Monomer/Dimer
Monomer
Media Components
Luria Broth
Preparation and Storage
12 months from date of receipt when stored at -20 degree C to-80 degree C as supplied.
1 month when stored at 4 degree C after reconstituting as directed.
3 months when stored at -20 degree C to -80 degree C after reconstituting as directed.
Active Protein Note
Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
Other Notes
Small volumes of MIP-3 beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MIP-3 beta active protein
Macrophage inflammatory protein-3 beta (MIP-3-beta), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3-beta signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3-beta also functions during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs. Human MIP-3-beta shows activity on mouse cells.

NCBI/Uniprot data below describe general gene information for MIP-3 beta. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8.8
NCBI Official Full Name
C-C motif chemokine 19
NCBI Official Synonym Full Names
C-C motif chemokine ligand 19
NCBI Official Symbol
CCL19  [Similar Products]
NCBI Official Synonym Symbols
ELC; CKb11; MIP3B; MIP-3b; SCYA19
  [Similar Products]
NCBI Protein Information
C-C motif chemokine 19
UniProt Protein Name
C-C motif chemokine 19
UniProt Synonym Protein Names
Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Macrophage inflammatory protein 3 beta; MIP-3-beta; Small-inducible cytokine A19
UniProt Gene Name
CCL19  [Similar Products]
UniProt Synonym Gene Names
ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta  [Similar Products]
NCBI Summary for MIP-3 beta
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
UniProt Comments for MIP-3 beta
CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding; chemokine activity; chemokine receptor binding

Biological Process: activation of JNK activity; cell communication; cell maturation; cellular calcium ion homeostasis; dendritic cell chemotaxis; establishment of T cell polarity; formation of immunological synapse; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; myeloid dendritic cell chemotaxis; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; positive regulation of endocytosis; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of receptor-mediated endocytosis; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of tumor necrosis factor production; release of sequestered calcium ion into cytosol; response to virus; T cell costimulation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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