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mKGF recombinant protein :: Keratinocyte Growth Factor Recombinant Protein

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Catalog # MBS144085
Unit / Price
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  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $4,585 +5 FREE 8GB USB
mKGF recombinant protein
Product Name

Keratinocyte Growth Factor (mKGF), Recombinant Protein

Full Product Name

Recombinant Mouse Keratinocyte Growth Factor

Product Synonym Names
KGF Mouse; Keratinocye Growth Factor Mouse Recombinant; HBGF-7; FGF7; FGF-7; KGF; Keratinocyte growth factor; Fibroblast growth factor 7; Heparin-binding growth factor 7
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MCNDMSPEQT ATSVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI RTVAVGIVAI KGVESEYYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNQK GIPVKGKKTK KEQKTAHFLP MAIT
3D Structure
ModBase 3D Structure for P36363
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by: (a) Analysis by HPLC. (b) Analysis by SDS-PAGE.
Form/Format
The protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Phosphate buffer pH-8 and 0.1M NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized KGF in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The ED50, calculated by the dose-dependant stimulation of KGF-responsive BaF3 indicator cells (measured by 3H-thymidine uptake) is < 10ng/ml corresponding to a specific activity of 100,000 Units/mg.
Preparation and Storage
Lyophilized KGF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF7 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Other Notes
Small volumes of mKGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
mKGF recombinant protein
Description: Keratinocyte Growth Factor-1 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 164 amino acids and having a molecular mass of 18.9 kDa. The FGF-7 is purified by proprietary chromatographic techniques.

Introduction: KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
NCBI/Uniprot data below describe general gene information for mKGF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
22,347 Da
NCBI Official Full Name
fibroblast growth factor 7
NCBI Official Synonym Full Names
fibroblast growth factor 7
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
fibroblast growth factor 7; FGF-7; HBGF-7; Keratinocyte growth factor; heparin-binding growth factor 7
UniProt Protein Name
Fibroblast growth factor 7
UniProt Synonym Protein Names
Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; KGF
UniProt Gene Name
UniProt Synonym Gene Names
Fgf-7; Kgf; FGF-7; HBGF-7; KGF  [Similar Products]
UniProt Entry Name
FGF7_MOUSE
UniProt Comments for mKGF
FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; receptor binding; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: positive regulation of keratinocyte migration; fibroblast growth factor receptor signaling pathway; hair follicle morphogenesis; wound healing; mesenchymal cell proliferation; phospholipid biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; ovarian follicle development; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; phosphatidylcholine biosynthetic process; surfactant homeostasis; positive regulation of epithelial cell proliferation; lung development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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