NP_689862
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
mixed lineage kinase domain-like protein isoform 1
NCBI Official Synonym Full Names
mixed lineage kinase domain like pseudokinase
NCBI Official Synonym Symbols
NCBI Protein Information
mixed lineage kinase domain-like protein
UniProt Protein Name
Mixed lineage kinase domain-like protein
UniProt Entry Name
MLKL_HUMAN
NCBI Summary for MLKL
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for MLKL
MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; TKL-Unique family
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding; protein complex binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: protein amino acid phosphorylation
Research Articles on MLKL
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Products associated with MLKL blocking peptide
Pathways associated with MLKL blocking peptide
Diseases associated with MLKL blocking peptide
Organs/Tissues associated with MLKL blocking peptide
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