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MLL3 elisa kit :: Human myeloid/lymphoid or mixed-lineage leukemia 3 ELISA Kit

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Catalog # MBS9321421
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MLL3 elisa kit
Product Name

myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), ELISA Kit

Full Product Name

Human Histone-lysine N-methyltransferase MLL3, MLL3 ELISA Kit

Product Synonym Names
Human Histone-lysine N-methyltransferase MLL3 (MLL3) ELISA kit; DKFZp686C08112; FLJ12625; FLJ38309; HALR; KIAA1506; KMT2C; MGC119851; MGC119852; MGC119853; ALR-like protein; histone-lysine N-methyltransferase; H3 lysine-4 specific; myeloid/lymphoid or mixed-lineage leukemia 3
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
606833
3D Structure
ModBase 3D Structure for Q8NEZ4
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of MLL3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for MLL3purchase
MBS9321421 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MLL3. The ELISA analytical biochemical technique of the MBS9321421 kit is based on MLL3 antibody-MLL3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MLL3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MLL3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for MLL3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
541,370 Da
NCBI Official Full Name
histone-lysine N-methyltransferase 2C
NCBI Official Synonym Full Names
lysine (K)-specific methyltransferase 2C
NCBI Official Symbol
KMT2C  [Similar Products]
NCBI Official Synonym Symbols
HALR; MLL3
  [Similar Products]
NCBI Protein Information
histone-lysine N-methyltransferase 2C; ALR-like protein; homologous to ALR protein; histone-lysine N-methyltransferase MLL3; myeloid/lymphoid or mixed-lineage leukemia protein 3; histone-lysine N-methyltransferase, H3 lysine-4 specific
UniProt Protein Name
Histone-lysine N-methyltransferase 2C
UniProt Synonym Protein Names
Homologous to ALR protein; Myeloid/lymphoid or mixed-lineage leukemia protein 3
UniProt Gene Name
KMT2C  [Similar Products]
UniProt Synonym Gene Names
HALR; KIAA1506; MLL3; Lysine N-methyltransferase 2C  [Similar Products]
UniProt Entry Name
KMT2C_HUMAN
NCBI Summary for MLL3
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
UniProt Comments for MLL3
MLL3: a protein methyltransferase that methylates K4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation. Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplication of the MLL3 gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. Contributes to genome-scale circadian transcription. May be involved in leukemogenesis and developmental disorder. Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. Belongs to the protein lysine methyltransferase family. TRX/MLL subfamily. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific)

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; histone H3-K4 methylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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