NP_002414.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,677 Da
NCBI Official Full Name
matrilysin preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 7 (matrilysin, uterine)
NCBI Protein Information
matrilysin; matrin; matrix metalloproteinase 7 (matrilysin, uterine); matrix metalloproteinase-7; pump-1 protease; uterine matrilysin; uterine metalloproteinase
UniProt Protein Name
Matrilysin
UniProt Synonym Protein Names
Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase
UniProt Synonym Gene Names
UniProt Entry Name
MMP7_HUMAN
NCBI Summary for MMP-7
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
UniProt Comments for MMP-7
MMP7: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Belongs to the peptidase M10A family.
Protein type: EC 3.4.24.23; Secreted, signal peptide; Protease; Secreted
Chromosomal Location of Human Ortholog: 11q22.2
Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity
Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; defense response to Gram-positive bacterium; antibacterial peptide biosynthetic process; proteolysis; defense response to Gram-negative bacterium; antibacterial peptide secretion; regulation of cell proliferation
Research Articles on MMP-7
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Products associated with MMP-7 elisa kit
Pathways associated with MMP-7 elisa kit
Diseases associated with MMP-7 elisa kit
Organs/Tissues associated with MMP-7 elisa kit
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