B4DN15
[Other Products]
UniProt Related Accession #
Molecular Weight
46,266 Da
NCBI Official Synonym Full Names
matrix metallopeptidase 1 (interstitial collagenase)
NCBI Official Synonym Symbols
NCBI Protein Information
interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1
UniProt Protein Name
cDNA FLJ55228, highly similar to Interstitial collagenase (EC 3.4.24.7)
UniProt Synonym Protein Names
cDNA FLJ55228, highly similar to Interstitial collagenase (EC 3.4.24.7)
UniProt Entry Name
B4DN15_HUMAN
NCBI Summary for MMP1
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
UniProt Comments for MMP1
MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Belongs to the peptidase M10A family.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; EC 3.4.24.7; Protease
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: proteinaceous extracellular matrix; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding
Biological Process: positive regulation of protein oligomerization; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; viral reproduction; proteolysis; blood coagulation; leukocyte migration
Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive
Research Articles on MMP1
Precautions
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Pathways associated with MMP1 elisa kit
Diseases associated with MMP1 elisa kit
Organs/Tissues associated with MMP1 elisa kit
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