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MNDA recombinant protein :: Myeloid Cell Nuclear Differentiation Recombinant Protein

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Catalog # MBS143561
Unit / Price
  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $5,015 +6 FREE 8GB USB
MNDA recombinant protein
Product Name

Myeloid Cell Nuclear Differentiation (MNDA), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Myeloid Cell Nuclear Differentiation Antigen

Product Synonym Names
MNDA Human; Myeloid Cell Nuclear Differentiation Antigen Human Recombinant; PYHIN3; Myeloid cell nuclear differentiation antigen; MNDA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
407
Sequence
MGSSHHHHHH SSGLVPRGSH MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN
OMIM
159553
3D Structure
ModBase 3D Structure for P41218
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The MNDA solution contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
Preparation and Storage
MNDA although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Other Notes
Small volumes of MNDA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MNDA recombinant protein
Description: MNDA Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 427 amino acids (1-407 a.a.) and having a molecular mass of 47.9 kDa. The MNDA is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: MNDA plays a role as a transcriptional activator/repressor in the myeloid lineage and in the granulocyte/monocyte cell-specific response to interferon. MNDA Stimulates the DNA binding of the transcriptional repressor protein YY1. MNDA is identified only in nuclei of cells of the granulocyte-monocyte lineage. A 200-a.a region of human MNDA is remarkably related to a region in the proteins encoded by a family of interferon-inducible mouse genes, MNDA participates in blood cell-specific responses to interferons.
NCBI/Uniprot data below describe general gene information for MNDA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
45,836 Da
NCBI Official Full Name
myeloid cell nuclear differentiation antigen
NCBI Official Synonym Full Names
myeloid cell nuclear differentiation antigen
NCBI Official Symbol
NCBI Official Synonym Symbols
PYHIN3
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NCBI Protein Information
myeloid cell nuclear differentiation antigen
UniProt Protein Name
Myeloid cell nuclear differentiation antigen
UniProt Gene Name
UniProt Entry Name
MNDA_HUMAN
NCBI Summary for MNDA
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
UniProt Comments for MNDA
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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