NP_002423.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
45,836 Da
NCBI Official Full Name
myeloid cell nuclear differentiation antigen
NCBI Official Synonym Full Names
myeloid cell nuclear differentiation antigen
NCBI Official Synonym Symbols
NCBI Protein Information
myeloid cell nuclear differentiation antigen
UniProt Protein Name
Myeloid cell nuclear differentiation antigen
UniProt Entry Name
MNDA_HUMAN
NCBI Summary for MNDA
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
UniProt Comments for MNDA
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Research Articles on MNDA
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Products associated with MNDA recombinant protein
Diseases associated with MNDA recombinant protein
Organs/Tissues associated with MNDA recombinant protein
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