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MOG recombinant protein :: Myelin Oligodendrocyte Glycoprotein Recombinant Protein

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Catalog # MBS197031
Unit / Price
  0.01 mg  /  $195 +1 FREE 8GB USB
  0.05 mg  /  $280 +1 FREE 8GB USB
  1 mg  /  $1,965 +2 FREE 8GB USB
MOG recombinant protein
Product Name

Myelin Oligodendrocyte Glycoprotein (MOG), Recombinant Protein

Also Known As

Recombinant Human Myelin Oligodendrocyte Glycoprotein

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (29624758..29640149). Location: 6p22.1
3D Structure
ModBase 3D Structure for Q16653
E Coli
Human Myelin Oligodendrocyte Glycoprotein
Greater than 95% as determined by SDS-PAGE and RPHPLC.
Lyophilized white powder from sterile-filtered solution in 20mM sodium acetate buffer, pH 4.0 and 0.3M NaCl. Purified by proprietary chromatographic techniques.
Reconstitute lyophilized MOG in sterile 10mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
Preparation and Storage
Although stable at room temperature for 3 weeks, the lyophilized product is best stored at or below -20 degree C. Upon reconstitution, MOG can be stored at 4 degree C for up to 1 week but is best stored at or below -20 degree C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
Other Notes
Small volumes of MOG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MOG recombinant protein
Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen in immunemediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.

Recombinant Human MOG produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids with a molecular weight of 15.2kDa. It is fused to a 6X His-tag at the C-terminus.
NCBI/Uniprot data below describe general gene information for MOG. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,193 Da[Similar Products]
NCBI Official Full Name
myelin-oligodendrocyte glycoprotein isoform alpha3
NCBI Official Synonym Full Names
myelin oligodendrocyte glycoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
MOGIG2; MGC26137
  [Similar Products]
NCBI Protein Information
myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; OTTHUMP00000029120; OTTHUMP00000029121; OTTHUMP00000029122; OTTHUMP00000029123; OTTHUMP00000029124; OTTHUMP00000029125; OTTHUMP00000029126; OTTHUMP00000029127; OTTHUMP00000109158; OTTHUMP00000214867; OTTHUMP00000214868; OTTHUMP00000214869
UniProt Protein Name
Myelin-oligodendrocyte glycoprotein
UniProt Gene Name
UniProt Entry Name
NCBI Summary for MOG
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
UniProt Comments for MOG
MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: plasma membrane; integral to membrane

Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion

Disease: Narcolepsy 7
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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