NP_787055.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,678 Da
NCBI Official Full Name
CTP synthase 2
NCBI Official Synonym Full Names
CTP synthase 2
NCBI Protein Information
CTP synthase 2; CTP synthase II; UTP-ammonia ligase 2; CTP synthetase type 2; cytidine 5'-triphosphate synthetase 2
UniProt Protein Name
CTP synthase 2
UniProt Synonym Protein Names
CTP synthetase 2; UTP--ammonia ligase 2
UniProt Entry Name
PYRG2_HUMAN
NCBI Summary for CTPS2
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for CTPS2
CTPS2: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. Belongs to the CTP synthase family.
Protein type: EC 6.3.4.2; Ligase; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: mitochondrion; cytosol
Molecular Function: CTP synthase activity; ATP binding
Biological Process: nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; glutamine metabolic process
Research Articles on CTPS2
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Pathways associated with CTPS2 elisa kit
Diseases associated with CTPS2 elisa kit
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