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anti-AFP antibody :: a-Fetoprotein Monoclonal Antibody

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Catalog # MBS660053
Unit / Price
  1 mg  /  $365 +1 FREE 8GB USB
anti-AFP antibody
Product Name

a-Fetoprotein (AFP), Monoclonal Antibody

Popular Item
Also Known As

Monoclonal mouse anti-human alpha-fetoprotein

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
609
OMIM
104150
Clonality
Monoclonal
Isotype
IgG1 for MAb 5H7
Clone Number
5H7
Specificity
MAbs react with different determinants of human alpha-fetoprotein.
MAbs do not cross-react with human albumin.
Purity/Purification
Chromatography on protein A Sepharose
Form/Format
PBS, pH 7.4, 0.1 % sodium azide (NaN3)
Concentration
3.4mg/ml (lot specific)
Volume
2 x 0.295ml
Clone Note
Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with purified human alpha-fetoprotein.
Material Safety Note
Product contians sodium azide as preservative. Although the amounth of sodium azide is very small appropriate care must be taken when handling this product.
Preparation and Storage
4 degree C (2 degree C - 8 degree C also allowed)
Other Notes
Small volumes of anti-AFP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Application Notes for anti-AFP antibody
We recommend the following pair in sandwich immunoassay (capture - detection): 4A3 - 5H7
NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,678 Da[Similar Products]
NCBI Official Full Name
alpha-fetoprotein
NCBI Official Synonym Full Names
alpha-fetoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
AFPD; FETA; HPAFP
  [Similar Products]
NCBI Protein Information
alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein
UniProt Protein Name
Alpha-fetoprotein
UniProt Synonym Protein Names
Alpha-1-fetoprotein; Alpha-fetoglobulin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HPAFP  [Similar Products]
UniProt Entry Name
FETA_HUMAN
NCBI Summary for AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
UniProt Comments for AFP
AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cytoplasm

Molecular Function: metal ion binding

Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle

Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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