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anti-SERPINA3 antibody :: Mouse Alpha-1-antichymotrypsin Monoclonal Antibody

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Catalog # MBS190008
Unit / Price
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  0.1 mg  /  $205 +1 FREE 8GB USB
  0.5 mg  /  $345 +1 FREE 8GB USB
  1 mg  /  $645 +1 FREE 8GB USB
anti-SERPINA3 antibody
Product Name

Alpha-1-antichymotrypsin (SERPINA3), Monoclonal Antibody

Full Product Name

Alpha-1-Antichymotrypsin Monoclonal Antibody

Product Synonym Names
Anti-Alpha-1-antichymotrypsin; Alpha-1-Anti-Chymotrypsin
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000014.8 (95078714..95090390). Location: 14q32.1
OMIM
107280
3D Structure
ModBase 3D Structure for P01011
Clonality
Monoclonal
Isotype
IgG2a
Host
Mouse
Specificity
Anti-Alpha-1-antichymotrypsin [Human serum alpha-1-antichymo-trypsin (4 clones). LP]
These antibodies specifically recognize alpha-1-antichymotrypsin.They do not cross-react with alpha-1-antitrypsin.
Form/Format
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
Antigen
Purified human serum alpha-1-antichymotrypsin.
Activity
Ig mg/ml* :30.0
ELISA Titer**:1:409,600
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against alpha-1-antichymotrypsin on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1)
Stabilizer
None
Preservatives
None. Available on request
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SERPINA3 antibody
Immunoassay
Application Notes for anti-SERPINA3 antibody
These antibodies may be used in immunoassays to detect and quantitate alpha-1-antichymotrypsin. Other applications are under investigation.
NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,651 Da[Similar Products]
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Official Symbol
SERPINA3  [Similar Products]
NCBI Official Synonym Symbols
ACT; AACT; GIG24; GIG25; MGC88254
  [Similar Products]
NCBI Protein Information
alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
UniProt Protein Name
Alpha-1-antichymotrypsin
UniProt Synonym Protein Names
Cell growth-inhibiting gene 24/25 protein; Serpin A3
Protein Family
UniProt Gene Name
SERPINA3  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
AACT_HUMAN
NCBI Summary for SERPINA3
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
UniProt Comments for SERPINA3
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; extracellular region; intracellular; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding

Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SERPINA3 antibody
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 Selenium Pathway antibodies  Selenium Pathway Diagram
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