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anti-SERPINA1 antibody :: Mouse Alpha-1-antitrypsin Monoclonal Antibody

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Catalog # MBS190009
Unit / Price
  0.1 mg  /  $195 +1 FREE 8GB USB
  0.5 mg  /  $330 +1 FREE 8GB USB
  1 mg  /  $615 +1 FREE 8GB USB
anti-SERPINA1 antibody
Product Name

Alpha-1-antitrypsin (SERPINA1), Monoclonal Antibody

Popular Item
Also Known As

Alpha-1-Antitrypsin Monoclonal Antibody

Product Synonym Names
Anti-Alpha-1-antitrypsin; Alpha-1- Anti-Trypsin
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
418
OMIM
107400
3D Structure
ModBase 3D Structure for P01009
Clonality
Monoclonal
Isotype
IgG2a
Host
Mouse
Specificity
Anti-Alpha-1-antitrypsin [Human serum alpha-1-antitrypsin (4 clones). LP]
These antibodies specifically recognize alpha-1-antitrypsin.They do not crossreact with alpha-1-antichymotrypsin.
Form/Format
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
Antigen
Purified human serum alpha- 1-antitrypsin.
Activity
Ig mg/ml* :22.0
ELISA Titer**:1:204,800
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against alpha-1-antitrypsin on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1)
Stabilizer
None
Preservatives
None. Available on request
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-SERPINA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SERPINA1 antibody
Immunoassay
Application Notes for anti-SERPINA1 antibody
These antibodies may be used in immunoassays to detect and quantitate alpha-1-antitrypsin. Other applications are under investigation.
NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
46,737 Da[Similar Products]
NCBI Official Full Name
alpha-1-antitrypsin
UniProt Protein Name
Alpha-1-antitrypsin
UniProt Synonym Protein Names
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
Protein Family
UniProt Gene Name
SERPINA1  [Similar Products]
UniProt Synonym Gene Names
AAT; PI  [Similar Products]
UniProt Entry Name
A1AT_HUMAN
NCBI Summary for SERPINA1
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPINA1
SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding

Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to methanol; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-SERPINA1 antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with SERPINA1 and FLNA
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