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anti-AFP antibody :: Alpha Fetoprotein (AFP) Monoclonal Antibody

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Catalog # MBS410049
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anti-AFP antibody
Product Name

Alpha Fetoprotein (AFP), Monoclonal Antibody

Popular Item
Full Product Name

Monoclonal Antibody to Alpha Fetoprotein (AFP)

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS410049 QC Report
Chromosome Location
Chromosome: 4; NC_000004.11 (74301933..74321492). Location: 4q13.3
OMIM
104150
3D Structure
ModBase 3D Structure for P02771
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
ME.101
Purity/Purification
Protein A chromatography from ascites
Purity: >95% determined by Size Exclusion Chromatography
Concentration
3.6mg/ml (lot specific)
Volume
278uL
Immunogen
Human fetal cord serum
Affinity
6 x 10^9 determined by Scatchard plot
pI
6.0-7.0
Expiration
11-01-2016
Buffer
0.15M PBS
Preservative
None
Preparation and Storage
Aliquot and store at -20C to -80C; avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of anti-AFP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AFP antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-fetoprotein
NCBI Official Synonym Full Names
alpha-fetoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
FETA; HPAFP
  [Similar Products]
NCBI Protein Information
alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein
UniProt Protein Name
Alpha-fetoprotein
UniProt Synonym Protein Names
Alpha-1-fetoprotein; Alpha-fetoglobulin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
HPAFP  [Similar Products]
UniProt Entry Name
FETA_HUMAN
NCBI Summary for AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
UniProt Comments for AFP
Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Subunit structure: Dimeric and trimeric forms have been found in addition to the monomeric form.

Subcellular location: Secreted.

Tissue specificity: Plasma. Synthesized by the fetal liver and yolk sac.

Developmental stage: Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.

Post-translational modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.Sulfated.

Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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