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anti-Ang-2 antibody :: Mouse Ang-2 Monoclonal Antibody

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Catalog # MBS335758
Unit / Price
  0.5 mg  /  $530 +1 FREE 8GB USB
anti-Ang-2 antibody
Product Name

Ang-2, Monoclonal Antibody

Popular Item
Full Product Name

Anti-Human Ang-2 Azide Free

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601922
Clonality
Monoclonal
Isotype
IgG2b Kappa light chain
Clone Number
B-C57
Host
Mouse
Specificity
Recognises both natural and recombinant human Angiopoietin-2
Form/Format
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free. Azide free
Hybridoma
Myeloma X63/AG.8653 x Balb/c node cells
Immunisation
Recombinant human Angiopoietin-2
Preparation and Storage
Store at 2-8 degree C for 12 months. For longer storage freeze aliquots.
Other Notes
Small volumes of anti-Ang-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Ang-2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for Ang-2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
angiopoietin-2 isoform c
NCBI Official Synonym Full Names
angiopoietin 2
NCBI Official Symbol
ANGPT2  [Similar Products]
NCBI Official Synonym Symbols
ANG2; AGPT2
  [Similar Products]
NCBI Protein Information
angiopoietin-2
UniProt Protein Name
Angiopoietin-2
UniProt Gene Name
ANGPT2  [Similar Products]
UniProt Synonym Gene Names
ANG-2  [Similar Products]
UniProt Entry Name
ANGP2_HUMAN
NCBI Summary for Ang-2
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for Ang-2
ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding

Biological Process: angiogenesis; germ cell development; leukocyte migration; maternal process involved in pregnancy; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; organ regeneration; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic substance; response to radiation; signal transduction; Tie receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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