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anti-APOH antibody :: Mouse APOLIPOPROTEIN H Monoclonal Antibody

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Catalog # MBS214131
Unit / Price
  2 mL  /  $440 +1 FREE 8GB USB
Testing Data
Product Name

APOLIPOPROTEIN H (APOH), Monoclonal Antibody

Full Product Name

MOUSE ANTI HUMAN APOLIPOPROTEIN H

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
138700
3D Structure
ModBase 3D Structure for P02749
Clonality
Monoclonal
Isotype
IgG1
Clone Number
ID2
Host
Mouse
Specificity
This item recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1.This protein is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, which is a process involved in the pathogenesis of recurrent miscarriage (anti phospholipid syndrome).
Form/Format
Tissue Culture Supernatant - liquid
Perservative Stabilisers
0.09% Sodium Azide
Histology Positive Control Tissue
Placenta
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-APOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-APOH antibody
MBS214131 recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1.This protein is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, which is a process involved in the pathogenesis of recurrent miscarriage (anti phospholipid syndrome).
Applications Tested/Suitable for anti-APOH antibody
Immunohistology Frozen, Western Blot (WB)

Testing Data of anti-APOH antibody
Staining of an 8.6 week placenta stained with Mouse anti Human Apolipoprotein H
anti-APOH antibody Testing Data image
NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,298 Da[Similar Products]
NCBI Official Full Name
beta-2-glycoprotein 1
NCBI Official Synonym Full Names
apolipoprotein H (beta-2-glycoprotein I)
NCBI Official Symbol
NCBI Official Synonym Symbols
BG; B2G1; B2GP1
  [Similar Products]
NCBI Protein Information
beta-2-glycoprotein 1; APC inhibitor; B2GPI; activated protein C-binding protein; anticardiolipin cofactor; apo-H; beta(2)GPI
UniProt Protein Name
Beta-2-glycoprotein 1
UniProt Synonym Protein Names
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
B2G1; Apo-H; B2GPI; Beta(2)GPI  [Similar Products]
UniProt Entry Name
APOH_HUMAN
NCBI Summary for APOH
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
UniProt Comments for APOH
APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface

Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding

Biological Process: negative regulation of angiogenesis; negative regulation of myeloid cell apoptosis; triacylglycerol metabolic process; negative regulation of fibrinolysis; positive regulation of blood coagulation; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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