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anti-B2M antibody :: Beta 2 Microglobulin Monoclonal Antibody

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Catalog # MBS310926
Unit / Price
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  0.2 mg  /  $580 +1 FREE 8GB USB
anti-B2M antibody
Product Name

Beta 2 Microglobulin (B2M), Monoclonal Antibody

Full Product Name

MAb to Beta 2 Microglobulin

Product Synonym Names
MAb to Beta 2-Microglobulin; Monoclonal Antibody to Beta 2-Microglobulin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 15; NC_000015.9 (45003685..45010357). Location: 15q21-q22.2
3D Structure
ModBase 3D Structure for P61769
Clone Number
Mouse. Hybridization of NS1/Ag4.1 myeloma cells with spleen cells from Balb/c mice.
Beta 2 Microglobulin
Specific for human Beta 2-microglobulin (MW 12kDa). Does not react with Beta 2-microglobulin from other species. Recognizes the HLA-Beta 2-microglobulin complex, free or associated with the membrane. The exact epitope for the antib
Purified, Lyophilized
Reconstitute with 1ml distilled water.
0.2mg/ml (prior to lyophilization) (lot specific)
Purified human Beta 2-microglobulin
Affinity Constant
Not determined
Lyophilized from PBS containing 1mg/ml BSA
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to one month at 2
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-B2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-B2M antibody
Immunohistochemistry - Formalin
Application Notes for anti-B2M antibody
Purification of HLA antigens associated with Beta 2-microglobulin.
Fluorescence microscopy or flow cytometry: 2ug/5x10^5 cells/test
Immunohistochemistry: Working dilution: 1:25 - 1:50 (suitable on frozen sections or cell smears)
Each laboratory s
NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,715 Da[Similar Products]
NCBI Official Full Name
NCBI Official Synonym Full Names
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules
UniProt Protein Name
Protein Family
UniProt Gene Name
UniProt Entry Name
NCBI Summary for B2M
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
UniProt Comments for B2M
B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: Golgi apparatus; extracellular space; focal adhesion; endoplasmic reticulum lumen; extracellular region; Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; plasma membrane; MHC class I protein complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Disease: Hypoproteinemia, Hypercatabolic
Product References and Citations for anti-B2M antibody
• Liabeuf A., et al., (1981), "An antigenic determinant of human Beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies", J. Immunol., 127; 1542-1548.

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