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anti-B2M antibody :: Beta 2 Microglobulin Monoclonal Antibody

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Catalog # MBS310926
Unit / Price
  0.2 mg  /  $580 +1 FREE 8GB USB
anti-B2M antibody
Product Name

Beta 2 Microglobulin (B2M), Monoclonal Antibody

Full Product Name

MAb to Beta 2 Microglobulin

Product Synonym Names
MAb to Beta 2-Microglobulin; Monoclonal Antibody to Beta 2-Microglobulin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 15; NC_000015.9 (45003685..45010357). Location: 15q21-q22.2
OMIM
109700
3D Structure
ModBase 3D Structure for P61769
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
B1G6
Host
Mouse. Hybridization of NS1/Ag4.1 myeloma cells with spleen cells from Balb/c mice.
Specificity
Beta 2 Microglobulin
Specific for human Beta 2-microglobulin (MW 12kDa). Does not react with Beta 2-microglobulin from other species. Recognizes the HLA-Beta 2-microglobulin complex, free or associated with the membrane. The exact epitope for the antib
Form/Format
Purified, Lyophilized
Reconstitute with 1ml distilled water.
Concentration
0.2mg/ml (prior to lyophilization) (lot specific)
Immunogen
Purified human Beta 2-microglobulin
Affinity Constant
Not determined
Buffer
Lyophilized from PBS containing 1mg/ml BSA
Preservative
No
Lyophilized
Yes
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to one month at 2
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-B2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-B2M antibody
Immunohistochemistry - Formalin
Application Notes for anti-B2M antibody
Purification of HLA antigens associated with Beta 2-microglobulin.
Fluorescence microscopy or flow cytometry: 2ug/5x10^5 cells/test
Immunohistochemistry: Working dilution: 1:25 - 1:50 (suitable on frozen sections or cell smears)
Each laboratory s
NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,715 Da[Similar Products]
NCBI Official Full Name
beta-2-microglobulin
NCBI Official Synonym Full Names
beta-2-microglobulin
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules
UniProt Protein Name
Beta-2-microglobulin
Protein Family
UniProt Gene Name
UniProt Entry Name
B2MG_HUMAN
NCBI Summary for B2M
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
UniProt Comments for B2M
B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: Golgi apparatus; extracellular space; focal adhesion; endoplasmic reticulum lumen; extracellular region; Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; plasma membrane; MHC class I protein complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Disease: Hypoproteinemia, Hypercatabolic
Product References and Citations for anti-B2M antibody
• Liabeuf A., et al., (1981), "An antigenic determinant of human Beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies", J. Immunol., 127; 1542-1548.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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