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anti-BORIS antibody :: Rat BORIS Monoclonal Antibody

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Catalog # MBS532845
Unit / Price
  0.1 mg  /  $315 +1 FREE 8GB USB
anti-BORIS antibody
Product Name

BORIS, Monoclonal Antibody

Popular Item
Also Known As

BORIS antibody

Product Synonym Names
Monoclonal BORIS; Anti-BORIS; Brother of the Regulator of Imprinted Sites
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
613
OMIM
607022
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
KT72
Host
Rat
Specificity
Mouse
Purity/Purification
BORIS antibody was purified by Protein G chromatography.
Form/Format
Supplied in PBS containing 0.1% sodium azide as a preservative
Concentration
1 mg/ml (lot specific)
Biological Significance
BORIS is a novel male germ-line-specific protein associated with epigenetic reprogramming events.
Biohazard Information
This product contains sodium azide which is hazardous
Immunogen
BORIS antibody was raised in Rat using Mouse BORIS as the immunogen.
Preparation and Storage
Store at 4 degree C for up to 1 month. For long term storage, aliquot and store at -20 to -80 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-BORIS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BORIS antibody
Rat monoclonal BORIS antibody
Product Categories/Family for anti-BORIS antibody
Applications Tested/Suitable for anti-BORIS antibody
Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-BORIS antibody
IF: 1-10 ug/ml
WB: 0.1-1 ug/ml
NCBI/Uniprot data below describe general gene information for BORIS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Secondary Accession #
Molecular Weight
35,417 Da
NCBI Official Full Name
BORIS-like protein
UniProt Protein Name
Transcriptional repressor CTCFL
UniProt Synonym Protein Names
Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein; Cancer/testis antigen 27; CT27; Zinc finger protein CTCF-T
UniProt Gene Name
CTCFL  [Similar Products]
UniProt Synonym Gene Names
BORIS; CT27  [Similar Products]
UniProt Entry Name
CTCFL_HUMAN
UniProt Comments for BORIS
BORIS: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; histone binding; sequence-specific DNA binding; metal ion binding

Biological Process: histone methylation; genetic imprinting; transcription, DNA-dependent; DNA methylation during gametogenesis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; regulation of histone H3-K4 methylation; cell cycle
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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