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anti-C1q antibody :: Mouse C1q Monoclonal Antibody

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Catalog # MBS214405
Unit / Price
  0.1 mL  /  $515 +1 FREE 8GB USB
anti-C1q antibody
Product Name

C1q, Monoclonal Antibody

Popular Item
Also Known As

MOUSE ANTI HUMAN C1q

Product Synonym Names
COMPLEMENT COMPONENT 1q; C1QG
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
120550
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3R9/2
Host
Mouse
Specificity
C1q
Form/Format
Purified IgG - liquid
Concentration
Approximate Protein Concentration: 1.0 mg/ml (lot specific)
Immunogen
Globular head domain of C1q, purified from human plasma
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Histology Positive Control Tissue
Kidney from patients with streptococcal glomerulonephritis.
Buffer Solution
Borate buffered saline
Target Species
Human
Preparation and Storage
Store at 4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from the date of despatch.
Other Notes
Small volumes of anti-C1q antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C1q antibody
Mouse anti human C1q antibody, clone 3R9/2, recognizes human complement component 1 q (C1q), a 156kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013).
Applications Tested/Suitable for anti-C1q antibody
Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-C1q antibody
Immunohistology - Frozen: 1:500-1:1000
Immunohistology: For best results MyBioSource recommends HISTAR detection kits.

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
NCBI/Uniprot data below describe general gene information for C1q. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,017 Da
NCBI Official Full Name
complement C1q subcomponent subunit A
NCBI Official Synonym Full Names
complement component 1, q subcomponent, A chain
NCBI Official Symbol
NCBI Protein Information
complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain
UniProt Protein Name
Complement C1q subcomponent subunit A
Protein Family
UniProt Gene Name
UniProt Entry Name
C1QA_HUMAN
NCBI Summary for C1q
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]
UniProt Comments for C1q
C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding

Biological Process: cell-cell signaling; innate immune response; complement activation, classical pathway; complement activation

Disease: C1q Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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